Stable, non-toxic gold nanorods lead to much improved biomedical treatment methodologies, as well as a host of other in-vivo applications

Stable, non-toxic gold nanorods lead to much improved biomedical treatment methodologies, as well as a host of other in-vivo applications

Stable, non-toxic gold nanorods lead to much improved biomedical treatment methodologies, as well as a host of other in-vivo applications

In recent years, biocompatible nanostructured materials have emerged as promising delivery systems for anticancer drugs, DNA and imaging agents. Specifically, colloidal gold nanoparticles (GNPs) with their fine tunable optical and electrical properties, allow implementations in cancer diagnosis and photothermal therapy.  GNPs are able to convert adsorbed light into localized thermal energy via surface plasmon resonance mechanism and ablates targeted solid tumors [1-2].

Conventional spherical GNPs display wavelength adsorption between 500-550 nm which is insufficient for tissue penetration. However, gold nanorods (GNRs), due to the morphological aspect ratio, show near-IR absorbing properties from about 700 to 800 nm which boosts their value in photothermal cancer therapy [2].

The most common synthetic method of GNRs involves cetyltrimethylammonium bromide (CTAB) for colloidal stabilization.  This material is a major barrier in the application of GNR-based materials, especially for in-vivo applications. CTAB is a cytotoxic material which is why its removal from the particle surface is one of the primary challenges. It is believed that complete removal of CTAB from GNRs will ultimately lead to the best cell viability of the GNRs [3-4].

In collaboration with SONA Nanotech, Strem Chemicals presents CTAB free GNRs designed for life sciences and specifically in-vivo human applications:

 

Catalog # Name Axial Diameter Wavelength
79-7010 Gold Gemini Nanorods; CTAB Free 13-18 nm 650 nm
79-7015 Gold Gemini Nanorods; CTAB Free 13-18 nm 700 nm
79-7020 Gold Gemini Nanorods; CTAB Free 10-13 nm 750 nm
79-7025 Gold Gemini Nanorods; CTAB Free 10-13 nm 800 nm
79-7030 Gold Gemini Nanorods; CTAB Free 9-12 nm 850 nm

 

GNRs, with tunable electro-optical properties and controlled with minimum amount of surfactants, allow their application not only for certain biomedical properties, but also for colorimetric and fluorescent detections, imaging macrophage activity, electrochemical gas sensing/biosensing and catalytic application [5-7]. Strem Chemicals also offers ascorbic acid and CTAB stabilized gold nanorods:

Catalog # Name Axial Diameter Wavelength
79-0136 Gold Nanorods; contains CTAB Aspect Ratio: 3-3.5 680 nm
79-6000 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 25 nm 550 nm
79-6005 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 25 nm 600 nm
79-6010 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 25 nm 650 nm
79-6015 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 25 nm 700 nm
79-6020 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 10 nm 700 nm
79-6025 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 10 nm 750 nm
79-6030 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 10 nm 780 nm
79-6035 Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB 10 nm 808 nm

 

In addition, Strem Chemicals offers three different gold nanorod kits.

Catalog # Name
96-1549 Gold Gemini Nanorods Kit, CTAB Free (Wavelength 650-850 nm)
96-1530 Gold Nanorods Kit (Axial Diameter – 25 nm, wavelength 550-700 nm)
96-1535 Gold Nanorods Kit (Axial Diameter – 10 nm, wavelength 700-808 nm)

 

References:

  1. E. Carrasco et al. Adv. Funct. Mater. 2015, 25, 615-626
  2. Lakhani et al, Nanotechnology 26 (2015) 432001 and references are therein
  3. C. Kinnear et al. Angew. Chem. Intern. Ed., 2014, 53, 12613-12617.
  4. L. Vigderman et al.Angew. Chem. Int. Ed. 2012, 51, 636-641.
  5. J. Olson et al. Chem. Soc. Rev., 2015, 44, 40-57
  6. M Baaske et al; Nature Nanotechnology, 2014, 9, 933-939
  7. Bo et al, ACS Nano, 2013, 7, 5993-6000

 

Visit the below link to view additional details on our website:

Gold Nanorods Synthesized without CTAB

 

gold-ctab-free